Diego Colón de Toledo, 4th Admiral of the Indies

Diego Colón de Toledo y Pravia, 4th Admiral of the Indies (– January 28, 1578), was a paternal grandson of Diego Colón and wife María de Toledo y Rojas. Making him a great-grandson of Christopher Columbus.

He married his first cousin Felipa Colón de Toledo, 3rd Duchess of Veragua, the second daughter and heiress of Luis Colón de Toledo, 2nd Duke of Veragua, and first wife María de Mosquera y Pasamonte, without issue. He held that office, which she had inherited, in her place.