Isabel de Bragança

Isabel de Bragança (1402-1465)
d/o dom AFONSO de Portugal Conde de Ourem e Arrayolos [later Duque de Bragança] & Brites Pereira Condesa de Barcellos (1402-1465)
x JOÃO de Portugal Duque de Beja

-Infante don JUAN de Castilla y León, ...m secondly (Madrigalejo [15] Aug 1447) Infanta dona ISABEL de Portugal, daughter of Infante dom JOÃO de Portugal Duque de Beja & his wife dona Isabel de Bragança ([1428]-Arevalo 15 Aug 1496, bur Carthusian convent at Miraflora near Burgos). When her husband died, she retired with her two children to the fortress of Arevalo, where she gradually went insane. https://fmg.ac/Projects/MedLands/CASTILE.htm#JuanIIdied1454B
-dona ISABEL de Portugal, daughter of dom AFONSO de Portugal Conde de Ourem e Arrayolos [later Duque de Bragança] & his first wife Brites Pereira Condesa de Barcellos (Oct 1402-Arevalo 26 Oct 1465, bur Batalla). https://fmg.ac/Projects/MedLands/PORTUGAL.htm#Isabeldied1496

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Isabella of Braganza (1414–1476), also known as Isabella of Barcelos (her father was originally the 8th Count of Barcelos). She was the daughter of Afonso, 1st Duke of Braganza and Beatriz Pereira Alvim, she married Infante João, Lord of Reguengos de Monsaraz, her half-uncle, son of John I of Portugal.

Isabella was the grandmother of both Manuel I of Portugal and Isabella I of Castile, through her granddaughter Isabella is the great great grandmother of Charles V, Holy Roman Emperor and Ferdinand I, Holy Roman Emperor, Isabella is also the great grandmother Catherine of Aragon and there for is the great great grandmother of Mary I of England. Her daughter Beatriz was also the mother of Leonor of Viseu who married John II of Portugal in January 1471. Beatriz had another daughter, Isabella of Viseu who married Fernando II, Duke of Braganza and was the mother of Jaime, Duke of Braganza and Dinis of Portugal.

Isabella and Infante John had four children:

Infante Diogo of Portugal (1425-1433) - 4th Constable and 11th Master of the Order of St. James;

Infanta Isabel of Portugal (1428-1496), who was the mother of Isabella I of Castile and an ancestor of Spanish, French and English monarchs;

Infanta Beatriz of Portugal, the mother of Manuel I of Portugal, Isabella of Viseu and Leonor of Viseu, and an ancestor of Spanish and Portuguese monarchs:

Infanta Phillipa of Portugal (1432-1444), Lady of Almada

Isabella died sometime in 1476 at the age of 62, she is now ancestor of monarchs of many countries.

https://en.wikipedia.org/wiki/Isabel_of_Barcelos